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As potential xanthine bronchodilators related to Doxofylline (lb), 2-(7-theophyllineethyl)-1,3-dioxolane (3); 7-(3,3-dimethoxypropyl) theophylline(5), 2-methyl, 2-(7-theophyllinemethyl)-1,3- dioxolane (8a), 2-phenyl, 2-(7-theophyllinemethyl)-1,3-dioxolane (8b) and 2-(7-theophyllinemethyl) -1,3-benzodioxolane(14) were synthesized from theophylline (la).
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